Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27756554 | 0.84 | DHODH (0.36) | MEN1KMT2A | |
| SCHEMBL27696136 | 0.72 | EGFR (0.35) | MEN1HSP90AA1KMT2AATM | |
| SCHEMBL29089072 | 0.71 | KDM4E (0.33) | — | |
| SCHEMBL27696148 | 0.71 | PTGS2 (0.32) | MEN1KMT2A | |
| SCHEMBL27696135 | 0.69 | LMNA (0.36) | — | |
| SCHEMBL27696143 | 0.69 | DHODH (0.36) | — | |
| SCHEMBL27696130 | 0.69 | PDE5A (0.36) | MEN1KMT2A | |
| SCHEMBL27696153 | 0.68 | MEN1 (0.43) | MEN1HSP90AA1KMT2AATMTLR9 | |
| SCHEMBL27677532 | 0.67 | PTGS2 (0.30) | — | |
| SCHEMBL27745788 | 0.63 | GAA (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101027290-B | 2, 3-phthalazinone derivatives as AURORA-a kinase inhibitors | HOFFMANN LA ROCHE | 2010-05-12 | — | — | CN | disclosed |
| CN-101405001-A | Methods of inhibiting BTK and SYK protein kinases | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |
| CN-101027290-A | Novel 2,3-phthalazinone derivatives, as AURORA-A kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2007-08-29 | — | — | CN | disclosed |