Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | GLB1 | P16278 | 1/20 | 0.32 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27696143 | 0.85 | DHODH (0.36) | DHODHMAOBSTING1EGFRERBB2 | |
| SCHEMBL27696134 | 0.84 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL27677489 | 0.74 | TDP1 (0.34) | TDP1P2RX3 | |
| SCHEMBL27696148 | 0.70 | PTGS2 (0.32) | DHODHMEN1LMNAMAPTKMT2A | |
| SCHEMBL27696136 | 0.69 | EGFR (0.35) | MEN1LMNAMAPTKMT2AEGFR | |
| SCHEMBL27696130 | 0.68 | PDE5A (0.36) | MEN1LMNAMAPTKMT2ASTING1 | |
| SCHEMBL27696135 | 0.66 | LMNA (0.36) | LMNAMAPT | |
| SCHEMBL27696153 | 0.64 | MEN1 (0.43) | MEN1LMNAMAPTKMT2AMAOB | |
| SCHEMBL28433431 | 0.62 | L3MBTL1 (0.41) | MEN1MAPTKMT2AMAOBTDP1 | |
| SCHEMBL28766378 | 0.60 | KDM4E (0.35) | MEN1MAPTKMT2AEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101027290-B | 2, 3-phthalazinone derivatives as AURORA-a kinase inhibitors | HOFFMANN LA ROCHE | 2010-05-12 | — | — | CN | disclosed |
| CN-101405001-A | Methods of inhibiting BTK and SYK protein kinases | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |