Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28486861 | 0.66 | MEN1 (0.31) | GAAESR1ESR2MEN1KMT2A | |
| SCHEMBL28431611 | 0.66 | GAA (0.40) | GAAPOLBALDH1A1RAB9ASMN1; SMN2 | |
| Bromide SCHEMBL15201212 | 0.65 | MAPT (0.36) | GAAPOLBKDM4EALDH1A1ESR1 | |
| SCHEMBL16623702 | 0.64 | GPR3 (0.50) | GAAPOLBKDM4EALDH1A1GPR3 | |
| SCHEMBL20537230 | 0.63 | RAB9A (0.51) | GAAPOLBKDM4EALDH1A1RAB9A | |
| SCHEMBL11568575 | 0.60 | CYP2D6 (0.37) | GAAPOLBALDH1A1RAB9AHSD17B10 | |
| SCHEMBL224931 | 0.59 | GPR3 (0.41) | POLBALDH1A1GPR3MEN1KMT2A | |
| SCHEMBL29711937 | 0.59 | GPR3 (0.41) | POLBALDH1A1GPR3MEN1KMT2A | |
| SCHEMBL918436 | 0.58 | KMT2A (0.61) | GAAKDM4ERAB9AESR1ESR2 | |
| SCHEMBL17014574 | 0.58 | IDO1 (0.43) | GAAPOLBKDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101336227-A | Nuclear receptor binding agents | GTX INC (US) | 2008-12-31 | — | — | CN | claimed |
| CN-102702013-B | Nuclear receptor binding agents | GTX INC. (US) | 2016-02-10 | — | — | CN | disclosed |
| CN-102351732-B | Nuclear receptor binding agents | GTX INC. (US) | 2014-10-29 | — | — | CN | disclosed |
| CN-102702013-A | Nuclear receptor binding agents | GTX INC | 2012-10-03 | — | — | CN | disclosed |
| CN-102351732-A | Nuclear receptor binding agents | GTX INC | 2012-02-15 | — | — | CN | disclosed |
| CN-101336227-A | Nuclear receptor binding agents | GTX INC (US) | 2008-12-31 | — | — | CN | disclosed |