Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 5/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28658782 | 0.88 | DAO (0.42) | KDM4EDAOFLT3IDO1NR3C1 | |
| SCHEMBL27613737 | 0.82 | LOXL2 (0.54) | PCSK9KDM4EALDH1A1LMNADAO | |
| SCHEMBL28072238 | 0.82 | LOXL2 (0.54) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL27648957 | 0.82 | CYP2A6 (0.42) | KDM4EALDH1A1HPGDCYP2C19TDP1 | |
| SCHEMBL27650372 | 0.82 | CYP19A1 (0.39) | FLT3IDO1TDO2MTNR1AMTNR1B | |
| SCHEMBL28038999 | 0.82 | NR3C1 (0.39) | KDM4ENR3C1MTNR1AMTNR1B | |
| SCHEMBL27488329 | 0.80 | LOXL2 (0.50) | MTNR1AMTNR1B | |
| SCHEMBL28672705 | 0.80 | LOXL2 (0.58) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL27597896 | 0.80 | MTNR1A (0.34) | MTNR1AMTNR1B | |
| SCHEMBL28291609 | 0.80 | MTNR1A (0.37) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379041-B | Tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole structural element, their preparation and their therapeutic use | SANOFI AVENTIS | 2012-08-29 | — | — | CN | disclosed |
| CN-101010297-B | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS | 2011-07-27 | — | — | CN | disclosed |
| CN-101115718-B | N- (heteroaryl) -1H-indole-2-carboxamide derivatives and their use for the preparation of a medicament for the prevention or treatment of diseases related to the capsaicin TRPV1 receptor | SANOFI AVENTIS | 2011-06-08 | — | — | CN | disclosed |
| CN-102007100-A | Compounds and compositions as modulators of GPR119 activity | IRM LLC | 2011-04-06 | — | — | CN | disclosed |
| CN-101379041-A | Tricyclic N-heteroaryl-amide derivatives containing benzimidazole structural units, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2009-03-04 | — | — | CN | disclosed |
| CN-101115718-A | N- (heteroaryl) -1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands | SANOFI AVENTIS (FR) | 2008-01-30 | — | — | CN | disclosed |
| CN-101010297-A | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS (FR) | 2007-08-01 | — | — | CN | disclosed |