Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28291596 | 0.89 | MTNR1A (0.37) | MTNR1AMTNR1BHDAC3HDAC4HDAC1 | |
| SCHEMBL28038688 | 0.86 | KDM4E (0.40) | MTNR1AMTNR1BFFAR1SMN1; SMN2 | |
| SCHEMBL28072238 | 0.80 | LOXL2 (0.54) | MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL27613737 | 0.80 | LOXL2 (0.54) | MTNR1AMTNR1BFFAR1SIRT1PYGL | |
| SCHEMBL27650372 | 0.80 | CYP19A1 (0.39) | MTNR1AMTNR1BFFAR1HDAC3HDAC4 | |
| SCHEMBL27648957 | 0.80 | CYP2A6 (0.42) | MTNR1AMTNR1BSIRT1SMN1; SMN2BACE1 | |
| SCHEMBL27697394 | 0.80 | PCSK9 (0.42) | MTNR1AMTNR1B | |
| SCHEMBL28819115 | 0.78 | MTNR1A (0.43) | MTNR1AMTNR1BHDAC2SIRT1SMN1; SMN2 | |
| SCHEMBL28872616 | 0.78 | MMP2 (0.48) | MTNR1AMTNR1BSIRT1SMN1; SMN2BACE1 | |
| SCHEMBL27488329 | 0.78 | LOXL2 (0.50) | MTNR1AMTNR1BHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748840-A | A kind of synthetic method of 2- substituted indole derivative | 中国医学科学院药物研究所 | 2019-05-14 | — | — | CN | disclosed |
| CN-1505613-A | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-gamma binding agents | ʷ��˿�������ȳ�ķ����˾ | 2004-06-16 | — | — | CN | disclosed |