Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | GALR3 | O60755 | 1/20 | 0.64 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | TNF | P01375 | 2/20 | 0.57 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423236 | 0.93 | RAB9A (0.73) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL5580128 | 0.85 | TNF (0.72) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL8506192 | 0.84 | HTT (0.63) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL8496629 | 0.81 | HTT (0.71) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL31044777 | 0.81 | NPC1 (0.43) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL1901540 | 0.80 | HTT (0.62) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL27697469 | 0.80 | NPC1 (0.49) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL8515605 | 0.78 | KMT2A (0.57) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL17456981 | 0.78 | SMN1; SMN2 (1.00) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL8490156 | 0.78 | HTT (0.60) | RAB9ALMNAHTTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061122-A | Novel thieno-pyridine and thieno-pyrimidine derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-24 | — | — | CN | disclosed |