Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2673123 | 0.83 | KDM4E (0.55) | KDM4EMAPTPOLBGAANPSR1 | |
| SCHEMBL2847756 | 0.82 | ICMT (0.51) | KDM4EMAPTPOLBGAANPSR1 | |
| SCHEMBL9157807 | 0.80 | KDM4E (0.46) | KDM4EMAPTPOLBPDGFRBFGFR1 | |
| SCHEMBL14564356 | 0.77 | NR4A2 (0.58) | KDM4EMAPTNR4A2PKMNPC1 | |
| SCHEMBL3267595 | 0.74 | HTR2C (0.44) | KDM4EMAPTPOLBNPC1GPR17 | |
| SCHEMBL21255987 | 0.73 | MTNR1A (0.59) | KDM4EMAPTNR4A2POLBPKM | |
| SCHEMBL6064603 | 0.72 | MTNR1A (0.37) | KDM4EMAPTPOLBPKMMTNR1A | |
| SCHEMBL27531827 | 0.72 | GPR17 (0.42) | KDM4EMAPTNR4A2PKMMTNR1A | |
| SCHEMBL20551235 | 0.71 | KMT2A (0.51) | KDM4EMAPTPOLBPKMCASP1 | |
| SCHEMBL9756250 | 0.71 | NR4A2 (0.43) | KDM4EMAPTNR4A2POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101018781-A | Bicyclic N-anilide spirolactam CGRP receptor antagonists | MERCK & CO INC (US) | 2007-08-15 | — | — | CN | disclosed |