Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1587240 | 0.84 | HTR2A (0.57) | HTR2CCYP2D6HTR2AHTR1AMAPT | |
| Hydrochloric Acid SCHEMBL7817897 | 0.83 | HTR2A (0.55) | HTR2CCYP2D6HTR2AHTR1AMAPT | |
| SCHEMBL2673123 | 0.78 | KDM4E (0.55) | GPR17GPR84KDM4EPOLBMAPT | |
| SCHEMBL2255648 | 0.77 | HTR2A (0.47) | HTR2CCYP2D6GPR84HTR2AHTR1A | |
| SCHEMBL2847756 | 0.77 | ICMT (0.51) | GPR17GPR84HTR2AKDM4EPOLB | |
| SCHEMBL2257565 | 0.76 | CSNK2A1 (0.45) | GPR84HTR2AKDM4EPOLBMAPT | |
| SCHEMBL11489734 | 0.76 | NR3C1 (0.37) | NPC1HTR2AMAPTRAB9AATM | |
| SCHEMBL3964357 | 0.75 | GPR84 (0.71) | HTR2CGPR84HTR2AHTR1AHTR1D | |
| SCHEMBL9157239 | 0.75 | GPR17 (0.47) | GPR17KDM4EPOLBMAPTGRIN2D | |
| SCHEMBL27697649 | 0.74 | KDM4E (0.41) | GPR17NPC1KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1541553-B1 | INDOLINE COMPOUND AND MEDICINAL USE THEREOF | KYOTO PHARMA IND (JP) | 2010-06-02 | — | — | EP | disclosed |
| US-7429612-B2 | Indoline compound and medicinal use thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| US-20060128787-A1 | Novel indoline compound and medicinal use thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2006-06-15 | — | — | US | disclosed |
| US-RE38970-E1 | Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2006-02-07 | — | — | US | disclosed |
| EP-1541553-A1 | NOVEL INDOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0866059-B1 | NOVEL HETEROCYCLIC DERIVATIVES AND MEDICINAL USE THEREOF | KYOTO PHARMA IND (JP) | 2001-12-05 | — | — | EP | disclosed |
| US-6200988-B1 | TETRAHYDROQUINOLINE DERIVATES; INHIBITORS OF ACYL COA:CHOLESTEROL ACYLTRANSFERASE AND LIPOPEROXIDATION; ARTERIOSCLEROSIS: CARDIOVASCULAR AND BRAIN DISORDERS | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-03-13 | — | — | US | disclosed |
| US-6063806-A | CARBOXY ACID OR ESTER DERIVATIVES OF INDOLINE OR INDOLE | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128787-A1 | Novel indoline compound and medicinal use thereof | ACAT2, ACAT1, ACOX1 | HTR2C 1563/4885CYP2D6 547/4885GPR17 1649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.