Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167001 | 0.84 | CA1 (0.50) | CA1CA2XDHSLC22A12ENPP3 | |
| SCHEMBL2771819 | 0.84 | CA1 (0.50) | CA1CA2XDHSLC22A12ENPP3 | |
| SCHEMBL4704448 | 0.84 | CA1 (0.50) | CA1CA2XDHSLC22A12ENPP3 | |
| SCHEMBL27663210 | 0.81 | CA1 (0.47) | CA1CA2XDHSLC22A12ENPP3 | |
| SCHEMBL4161556 | 0.81 | CA1 (0.47) | CA1CA2XDHSLC22A12MEN1 | |
| SCHEMBL15356390 | 0.80 | KDM4E (0.48) | CA1CA2XDHSLC22A12MEN1 | |
| SCHEMBL2185041 | 0.77 | NQO2 (0.55) | CA1CA2XDHSLC22A12MEN1 | |
| SCHEMBL29482237 | 0.75 | CA1 (0.56) | CA1CA2XDHSLC22A12ENPP3 | |
| SCHEMBL7304752 | 0.75 | CA1 (0.61) | CA1CA2XDHSLC22A12MEN1 | |
| SCHEMBL819485 | 0.75 | CA1 (0.56) | CA1CA2XDHSLC22A12ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753739-B1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LTD (GB) | 2010-04-28 | — | — | EP | disclosed |
| US-20090192194-A1 | Cyclic Amine Derivatives, Processes For Their Preparation, And Pharmaceutical Compositions Containing Them | ALVARO GIUSEPPE | 2009-07-30 | — | — | US | disclosed |
| US-7534893-B2 | Imidazol-2-one compounds useful in the treatment of various disorders | GLAXO GROUP LIMITED (GB) | 2009-05-19 | — | — | US | disclosed |
| US-20080262041-A1 | Beta-Lactams for Treatment of Cns Disorders | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| EP-1689737-B1 | BETA-LACTAMS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-07-16 | — | — | EP | disclosed |
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | GLAXO GROUP LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
| EP-1581495-B1 | 4-aryl-4-(naphth-1-ylmethylamino)methyl-piperidine compounds and their use | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| US-20070073061-A1 | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 2007-03-29 | — | — | US | disclosed |
| EP-1753739-A1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-02-21 | — | — | EP | disclosed |
| CN-1878764-A | Beta-lactams for treatment of cns disorders | GLAXO GROUP LTD (GB) | 2006-12-13 | — | — | CN | disclosed |
| US-20060058352-A1 | Piperidine amine compounds and their use | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1622871-A1 | CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 2006-02-08 | — | — | EP | disclosed |
| WO-2005121122-A1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
| US-20050245572-A1 | Naphthyl ether compounds and their use | OLINK AB (SE) | 2005-11-03 | — | — | US | disclosed |
| EP-1581495-A1 | PIPERIDINE AMINE COMPOUNDS AND THEIR USE | AstraZeneca AB (SE) | 2005-10-05 | — | — | EP | disclosed |
| EP-1546101-A1 | NAPHTHYL ETHER COMPOUNDS AND THEIR USE | AstraZeneca AB (SE) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005049600-A1 | BETA-LACTAMS FOR TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |
| WO-2004099143-A1 | CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004056771-A1 | PIPERIDINE AMINE COMPOUNDS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004022539-A1 | NAPHTHYL ETHER COMPOUNDS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262041-A1 | Beta-Lactams for Treatment of Cns Disorders | SLC7A1, TPH1, CHRNA10 | CA1 1918/4885CA2 2390/4885XDH 2206/4885 |
| US-20060058352-A1 | Piperidine amine compounds and their use | HRH3, H1-5, H1-0 | CA1 4060/4885CA2 3701/4885XDH 3722/4885 |
| US-20070073061-A1 | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | SLC6A4, OPRL1, HCRTR1 | CA1 2530/4885CA2 1755/4885XDH 3340/4885 |
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | SLC6A4, SLC18A2, SLC18A1 | CA1 1442/4885CA2 364/4885XDH 2289/4885 |
| US-20090192194-A1 | Cyclic Amine Derivatives, Processes For Their Preparation, And Pharmaceutical Compositions Containing Them | SLC6A4, OPRL1, HCRTR1 | CA1 2530/4885CA2 1755/4885XDH 3340/4885 |
| US-20050245572-A1 | Naphthyl ether compounds and their use | NR4A1, NPM1, H1-4 | CA1 3573/4885CA2 4278/4885XDH 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.