Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789632 | 0.87 | GRM2 (0.44) | ALDH1A1KDM4EPPARAPPARGLMNA | |
| SCHEMBL2769638 | 0.85 | LMNA (0.48) | ALDH1A1PKMPPARAPPARGKMT2A | |
| SCHEMBL2768427 | 0.85 | ALDH1A1 (0.44) | ALDH1A1PPARAMEN1KMT2AGAA | |
| SCHEMBL528101 | 0.83 | MAOA (0.49) | MAOAMAOBALDH1A1KDM4EGAA | |
| SCHEMBL2769712 | 0.83 | PPARA (0.53) | MAOAMAOBALDH1A1KDM4EPKM | |
| SCHEMBL2769998 | 0.83 | PPARA (0.55) | PPARAPPARGMEN1KMT2AGAA | |
| SCHEMBL21643462 | 0.81 | GAA (0.41) | PPARAKMT2AGAAMAPTHPGD | |
| SCHEMBL21643336 | 0.81 | ALDH1A1 (0.39) | ALDH1A1PPARAPPARGKMT2AGAA | |
| SCHEMBL410069 | 0.80 | PSEN1 (0.42) | ALDH1A1KDM4EPPARAPPARGMEN1 | |
| SCHEMBL21643230 | 0.79 | POLB (0.39) | ALDH1A1KDM4EPPARAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888303-B1 | SYNTHETIC DERIVATIVES OF RAPAMYCIN AS MULTIMERIZING AGENTS FOR CHIMERIC PROTEINS WITH IMMUNOPHILIN-DERIVED DOMAINS | ARIAD PHARMA INC (US) | 2010-04-21 | — | — | EP | disclosed |