Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27722211 | 0.89 | PLAU (0.35) | PLAUMMP1MMP7MMP8MMP12 | |
| SCHEMBL27722190 | 0.85 | NPC1 (0.32) | NPC1GAARAB9AMEN1KMT2A | |
| SCHEMBL27701758 | 0.84 | PLAU (0.40) | PLAUMMP1MMP7MMP8MMP12 | |
| SCHEMBL27722186 | 0.84 | HDAC1 (0.33) | HDAC6NPC1GAARAB9AMEN1 | |
| SCHEMBL27722330 | 0.80 | HDAC1 (0.40) | HDAC1 | |
| SCHEMBL27701807 | 0.78 | PLAU (0.44) | PLAUMMP1MMP7MMP8MMP12 | |
| SCHEMBL27722212 | 0.76 | PLAU (0.39) | PLAUMMP1MMP7MMP8MMP12 | |
| SCHEMBL27722215 | 0.76 | PABPC1 (0.34) | NPC1GAARAB9AMEN1KMT2A | |
| SCHEMBL28768875 | 0.76 | ALDH1A1 (0.43) | NPC1RAB9AMEN1KMT2AHDAC8 | |
| SCHEMBL27701698 | 0.75 | HDAC8 (0.45) | MEN1KMT2AHDAC8MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163703-B | Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG | 2010-12-15 | — | — | CN | disclosed |
| CN-101163703-A | Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG (CH) | 2008-04-16 | — | — | CN | disclosed |