Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27722212 | 0.88 | PLAU (0.39) | HDAC8KDM4EALDH1A1PLA2G1BMAPT | |
| SCHEMBL27701758 | 0.87 | PLAU (0.40) | HDAC8PLA2G1BMAPTMEN1KMT2A | |
| SCHEMBL27701734 | 0.86 | SMN1; SMN2 (0.41) | HDAC8KDM4EALDH1A1MAPTHTT | |
| SCHEMBL27701722 | 0.82 | HDAC1 (0.41) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL27722334 | 0.76 | HDAC6 (0.36) | HDAC8PLA2G1BMEN1KMT2ACYP3A4 | |
| SCHEMBL27722227 | 0.76 | NR1H4 (0.45) | HDAC8MEN1KMT2A | |
| SCHEMBL27701643 | 0.75 | TSHR (0.37) | HDAC8KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL28769725 | 0.74 | ATP4A (0.54) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27701655 | 0.74 | GAA (0.41) | HDAC8KDM4EALDH1A1PLA2G1BMAPT | |
| SCHEMBL28768873 | 0.74 | HDAC6 (0.38) | HDAC8KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163703-B | Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG | 2010-12-15 | — | — | CN | disclosed |
| CN-101163703-A | Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG (CH) | 2008-04-16 | — | — | CN | disclosed |