Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27722333 | 0.85 | PKM (0.33) | HDAC6HDAC8PKMHDAC1HDAC3 | |
| SCHEMBL27701649 | 0.83 | HDAC1 (0.37) | HDAC6HDAC8PKMHDAC1HDAC3 | |
| SCHEMBL28768873 | 0.81 | HDAC6 (0.38) | HDAC6HDAC8MEN1KMT2APKM | |
| SCHEMBL28772858 | 0.77 | HDAC8 (0.37) | HDAC6HDAC8MEN1KMT2AHDAC1 | |
| SCHEMBL27701698 | 0.76 | HDAC8 (0.45) | HDAC8MEN1KMT2APLA2G1BCYP3A4 | |
| SCHEMBL27701659 | 0.75 | HDAC6 (0.37) | HDAC6HDAC8MEN1KMT2AHDAC1 | |
| SCHEMBL27722270 | 0.73 | HDAC6 (0.39) | HDAC6HDAC8MEN1KMT2AHDAC1 | |
| SCHEMBL27722212 | 0.73 | PLAU (0.39) | HDAC6HDAC8MEN1KMT2AHDAC1 | |
| SCHEMBL27701823 | 0.73 | HDAC6 (0.38) | HDAC6HDAC8MEN1KMT2ARXFP1 | |
| SCHEMBL27701646 | 0.73 | PLAU (0.39) | HDAC6HDAC8MEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163703-B | Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG | 2010-12-15 | — | — | CN | disclosed |
| CN-101163703-A | Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG (CH) | 2008-04-16 | — | — | CN | disclosed |