Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | C1S | P09871 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27702378 | 1.00 | OGG1 (0.43) | OGG1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL5735423 | 0.83 | C1S (0.50) | L3MBTL1CYP1A2CYP2C19POLBKDM4E | |
| SCHEMBL5735430 | 0.83 | C1S (0.50) | L3MBTL1CYP1A2CYP2C19POLBKDM4E | |
| SCHEMBL8282535 | 0.83 | C1S (0.50) | L3MBTL1CYP1A2CYP2C19POLBKDM4E | |
| SCHEMBL27704646 | 0.76 | ALDH1A1 (0.61) | OGG1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL28067416 | 0.74 | MAOB (0.44) | OGG1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL5177153 | 0.73 | C1S (0.47) | L3MBTL1CYP1A2CYP2C19POLBKDM4E | |
| Bromobenzene SCHEMBL27368728 | 0.73 | ALDH1A1 (0.50) | CYP1A2CYP2C19CYP2D6ALDH1A1LMNA | |
| SCHEMBL16386232 | 0.72 | ALDH1A1 (0.50) | OGG1L3MBTL1CYP1A2CYP2C19POLB | |
| SCHEMBL15587046 | 0.72 | C1S (0.46) | OGG1L3MBTL1CYP1A2CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101084198-A | Substituted amino-pyrimidones and uses thereof | ASTRAZENECA AB (SE) | 2007-12-05 | — | — | CN | disclosed |
| CN-101084199-A | Substituted amino-compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-12-05 | — | — | CN | disclosed |