Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28246279 | 0.79 | NOX1 (0.38) | CA12CA1CA2CA4CA7 | |
| SCHEMBL27507927 | 0.79 | CA9 (0.31) | CA9 | |
| SCHEMBL18885231 | 0.74 | IDO1 (0.52) | RAB9ASNCABRD4MAPTTP53 | |
| SCHEMBL28787427 | 0.73 | SNCA (0.34) | TGM2CES1RAB9ACA12CA1 | |
| SCHEMBL19341456 | 0.73 | RAB9A (0.40) | TGM2CES1RAB9ACA12CA1 | |
| SCHEMBL25832613 | 0.73 | RAB9A (0.40) | TGM2CES1RAB9ACA12CA1 | |
| SCHEMBL27741244 | 0.72 | PDE4A (0.33) | — | |
| SCHEMBL27508187 | 0.72 | PGR (0.47) | BRD4 | |
| SCHEMBL24246218 | 0.69 | RAB9A (0.37) | RAB9ASNCANQO2 | |
| SCHEMBL28077552 | 0.69 | MAOA (0.37) | POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459027-A | 6-substituted-3H-1, 3-benzothiazol-2-one compounds as TARP-gamma 8 dependent AMPA receptor antagonists | 伊莱利利公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-102459227-B | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 | JANSSEN PHARMACEUTICA NV | 2014-08-20 | — | — | CN | disclosed |
| CN-102459223-A | 5-pyridin-3-yl-1, 3-dihydro-indol-2-one derivatives and their use as aldosterone synthase and/or CYP11B1 modulators | NOVARTIS AG | 2012-05-16 | — | — | CN | disclosed |
| CN-102459227-A | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 | JANSSEN PHARMACEUTICA NV | 2012-05-16 | — | — | CN | disclosed |
| CN-101189218-A | Benzothiazol-2-on derivatives as lipase and phospholipase inhibitors | SANOFI AVENTIS (FR) | 2008-05-28 | — | — | CN | disclosed |