Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 14/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260357 | 1.00 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1885410 | 0.88 | PTGS1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14209412 | 0.81 | HPGDS (0.46) | CTSAHPGDSBRD4 | |
| SCHEMBL1889856 | 0.76 | MAPT (0.46) | AURKA | |
| SCHEMBL1889859 | 0.76 | MAPT (0.46) | AURKA | |
| SCHEMBL4266768 | 0.76 | KEAP1 (0.51) | — | |
| SCHEMBL27705864 | 0.76 | KEAP1 (0.51) | — | |
| SCHEMBL6573037 | 0.76 | PRKCI (0.50) | HPGDS | |
| SCHEMBL1879819 | 0.75 | HPGDS (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30353435 | 0.75 | RXRA (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101184726-B | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG | 2012-05-30 | — | — | CN | claimed |
| CN-101184726-A | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG (IT) | 2008-05-21 | — | — | CN | claimed |
| CN-101184726-B | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG | 2012-05-30 | — | — | CN | disclosed |
| CN-101184726-A | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG (IT) | 2008-05-21 | — | — | CN | disclosed |