Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | USP9X | Q93008 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14209412 | 0.83 | HPGDS (0.46) | HPGDSLTA4HNOTUMBACE1BACE2 | |
| SCHEMBL1885410 | 0.76 | PTGS1 (0.46) | HPGDSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3964365 | 0.76 | HPGDS (0.58) | HPGDSLTA4HNOTUMBACE1BACE2 | |
| SCHEMBL4260357 | 0.75 | PSEN1 (0.43) | HPGDSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27705669 | 0.75 | PSEN1 (0.43) | HPGDSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9079901 | 0.73 | CTSK (0.48) | MEN1KMT2ACYP11B1CYP11B2CTSK | |
| SCHEMBL16159319 | 0.72 | HPGDS (0.55) | HPGDSLTA4HNOTUMBACE1BACE2 | |
| SCHEMBL1884956 | 0.72 | VNN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3098624 | 0.72 | RAB9A (0.51) | HPGDSLTA4HNOTUMBACE1HPGD | |
| SCHEMBL14983820 | 0.71 | HPGDS (0.43) | HPGDSLTA4HNOTUMBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939521-B2 | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DompePHA.R.MA S.p.A. (IT) | 2011-05-10 | — | — | US | disclosed |
| EP-1856031-B1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-02-25 | — | — | EP | disclosed |
| US-20080312293-A1 | 2-Arylpropionic Acid Derivatives and Pharmaceutical Compositions Containing Them | DOMPE' PHA.R.MA.S.P.A. (IT) | 2008-12-18 | — | — | US | disclosed |
| EP-1856031-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006063999-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' PHA.R.MA.S.P.A. (IT) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312293-A1 | 2-Arylpropionic Acid Derivatives and Pharmaceutical Compositions Containing Them | C3AR1, C5AR2, C5AR1 | HPGDS 109/4885LTA4H 274/4885USP9X 3938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.