Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27706478 | 0.90 | MEN1 (0.36) | — | |
| SCHEMBL5096924 | 0.82 | PIK3CA (0.43) | CYP11B1CYP11B2MCHR1DRD2HTR2A | |
| SCHEMBL27706480 | 0.81 | CHRM2 (0.31) | — | |
| SCHEMBL5091881 | 0.78 | ACHE (0.46) | DRD2DRD3DYRK1AWNT1GSK3B | |
| SCHEMBL27706491 | 0.77 | CYP11B1 (0.38) | CYP11B1CYP11B2DRD2HTR2ADRD3 | |
| SCHEMBL5091955 | 0.76 | DRD2 (0.49) | CYP11B1CYP11B2DRD2HTR2ADRD3 | |
| SCHEMBL27706460 | 0.76 | CYP11B1 (0.38) | CYP11B1CYP11B2 | |
| SCHEMBL5094873 | 0.76 | CYP1A2 (0.43) | CYP11B1CYP11B2CYP3A4DYRK1AWNT1 | |
| SCHEMBL5091017 | 0.75 | ABCB1 (0.43) | CYP11B1CYP11B2DRD2HTR2ADRD3 | |
| SCHEMBL5103707 | 0.74 | ACHE (0.38) | CYP11B1CYP11B2MCHR1HTR2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128458-A | Tricyclic delta opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | disclosed |