Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27706490 | 0.90 | CYP11B1 (0.36) | — | |
| SCHEMBL27706480 | 0.83 | CHRM2 (0.31) | CHRM2CHRM1CHRM3 | |
| SCHEMBL5103709 | 0.81 | GPR142 (0.40) | MEN1KMT2AALDH1A1ROCK2ROCK1 | |
| SCHEMBL27706479 | 0.76 | ROCK2 (0.35) | MEN1KMT2AALDH1A1ROCK2ROCK1 | |
| SCHEMBL5094872 | 0.74 | NISCH (0.36) | MEN1KMT2AALDH1A1ROCK2LMNA | |
| SCHEMBL5097000 | 0.74 | L3MBTL1 (0.41) | KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5090842 | 0.73 | MCHR1 (0.37) | ALDH1A1ROCK2ROCK1CHRM2CHRM1 | |
| SCHEMBL4510859 | 0.73 | MEN1 (0.33) | MEN1KMT2AALDH1A1ROCK2LMNA | |
| SCHEMBL4502719 | 0.71 | CHRNB2 (0.38) | ROCK2ROCK1 | |
| SCHEMBL5096924 | 0.71 | PIK3CA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128458-A | Tricyclic delta opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | disclosed |