SCHEMBL2770802

SCHEMBL2770802

COc1ccc(C(OC[C@@]23CO[C@@H]([C@H](n4cc(C)c(=O)[nH]c4=O)O2)[C@H]3OCc2ccccc2)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK2 O00142 10/20 0.40
TK1 P04183 7/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5558232 1.00 TK2 (0.40) TK2TK1
SCHEMBL2769235 0.88 TK2 (0.42) TK2TK1
SCHEMBL5582060 0.88 TK2 (0.42) TK2TK1
SCHEMBL24512779 0.88 TK2 (0.42) TK2TK1
SCHEMBL5557408 0.88 TK2 (0.42) TK2TK1
SCHEMBL2298778 0.88 TK2 (0.42) TK2TK1
SCHEMBL24512780 0.88 TK2 (0.38) TK2TK1
SCHEMBL25630027 0.86 TK2 (0.40) TK2TK1
SCHEMBL3841357 0.84 TK2 (0.40) TK2TK1
SCHEMBL1096648 0.84 TK1 (0.42) TK2TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161439-B1 XYLO-LNA ANALOGUES EXIQON AS (DK) 2010-04-21 EP disclosed
US-7084125-B2 Xylo-LNA analogues EXIQON A/S (DK) 2006-08-01 US disclosed
US-20030082807-A1 Xylo-LNA analogues QIAGEN GMBH (DE) 2003-05-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030082807-A1 Xylo-LNA analogues FBL, NSUN2, RNGTT TK2 1056/4885TK1 292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.