SCHEMBL5582060

SCHEMBL5582060

COc1ccc(C(OC[C@@]23CO[C@@H]([C@H](n4cc(C)c(=O)[nH]c4=O)O2)[C@@H]3O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK2 O00142 12/20 0.42
TK1 P04183 7/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5557408 1.00 TK2 (0.42) TK2TK1
SCHEMBL24512779 1.00 TK2 (0.42) TK2TK1
SCHEMBL2769235 1.00 TK2 (0.42) TK2TK1
SCHEMBL3841357 0.94 TK2 (0.40) TK2TK1
SCHEMBL19305222 0.92 TK2 (0.41) TK2TK1
SCHEMBL2298778 0.91 TK2 (0.42) TK2TK1
SCHEMBL25630027 0.91 TK2 (0.40) TK2TK1
SCHEMBL2770802 0.88 TK2 (0.40) TK2TK1
SCHEMBL5558232 0.88 TK2 (0.40) TK2TK1
SCHEMBL24512780 0.88 TK2 (0.38) TK2TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3728591-B1 GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CT COPENHAGEN AS (DK) 2025-07-23 EP disclosed
EP-3728590-B1 NOVEL THIOPHOSPHORAMIDITES ROCHE INNOVATION CT COPENHAGEN AS (DK) 2025-07-02 EP disclosed
CN-111448316-B Novel thiophosphorous acid amides 罗氏创新中心哥本哈根有限公司 2025-02-14 CN disclosed
US-20240368593-A1 GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2024-11-07 US disclosed
EP-3728592-B1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CT COPENHAGEN AS (DK) 2024-05-29 EP disclosed
US-11597926-B2 Thiophosphoramidites ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2023-03-07 US disclosed
US-11597926-B2 Thiophosphoramidites ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2023-03-07 US disclosed
US-20230002762-A1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2023-01-05 US disclosed
EP-4092117-A1 GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE Roche Innovation Center Copenhagen A/S (DK) 2022-11-23 EP disclosed
EP-4092118-A1 NOVEL THIOPHOSPHORAMIDITES Roche Innovation Center Copenhagen A/S (DK) 2022-11-23 EP disclosed
EP-4074724-A1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE Roche Innovation Center Copenhagen A/S (DK) 2022-10-19 EP disclosed
US-20220112493-A1 PHOSPHONOACETATE GAPMER OLIGONUCLEOTIDES ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2022-04-14 US disclosed
US-20220073916-A1 NOVEL PHOSPHORAMIDITES ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2022-03-10 US disclosed
US-20210115438-A1 NOVEL THIOPHOSPHORAMIDITES ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2021-04-22 US disclosed
US-20210115438-A1 NOVEL THIOPHOSPHORAMIDITES ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2021-04-22 US disclosed
US-20200339982-A1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2020-10-29 US disclosed
US-20200339982-A1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2020-10-29 US disclosed
US-20200332289-A1 GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2020-10-22 US disclosed
US-20070270370-A1 Novel bicyclonucleoside analogues SANKYO COMPANY, LIMITED (JP) 2007-11-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070270370-A1 Novel bicyclonucleoside analogues PURB, RNGTT, NSUN2 TK2 231/4885TK1 133/4885
US-20230002762-A1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE DUT, TYMP, TYMS TK2 76/4885TK1 26/4885
US-20220073916-A1 NOVEL PHOSPHORAMIDITES P2RY11, P2RX5, P2RX2 TK2 941/4885TK1 466/4885
US-20200339982-A1 OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE DUT, TYMP, TYMS TK2 59/4885TK1 34/4885
US-20210115438-A1 NOVEL THIOPHOSPHORAMIDITES TYMP, RRM2B, RNGTT TK2 146/4885TK1 123/4885
US-11597926-B2 Thiophosphoramidites TYMP, RRM2B, RRM2 TK2 163/4885TK1 110/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.