Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770802 | 1.00 | TK2 (0.40) | TK2TK1 | |
| SCHEMBL2769235 | 0.88 | TK2 (0.42) | TK2TK1 | |
| SCHEMBL5582060 | 0.88 | TK2 (0.42) | TK2TK1 | |
| SCHEMBL24512779 | 0.88 | TK2 (0.42) | TK2TK1 | |
| SCHEMBL5557408 | 0.88 | TK2 (0.42) | TK2TK1 | |
| SCHEMBL2298778 | 0.88 | TK2 (0.42) | TK2TK1 | |
| SCHEMBL24512780 | 0.88 | TK2 (0.38) | TK2TK1 | |
| SCHEMBL25630027 | 0.86 | TK2 (0.40) | TK2TK1 | |
| SCHEMBL3841357 | 0.84 | TK2 (0.40) | TK2TK1 | |
| SCHEMBL1096648 | 0.84 | TK1 (0.42) | TK2TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030083341-A1 | 2,3,5-Substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2003-05-01 | — | — | US | claimed |
| US-20010018525-A1 | 2, 3, 5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2001-08-30 | — | — | US | claimed |
| EP-1178999-B1 | L-RIBO-LNA ANALOGUES | SANTARIS PHARMA AS (DK) | 2007-03-14 | — | — | EP | disclosed |
| US-7053207-B2 | L-ribo-LNA analogues | EXIQON A/S (DK) | 2006-05-30 | — | — | US | disclosed |
| US-7008636-B2 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2006-03-07 | — | — | US | disclosed |
| US-20040214869-A1 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2004-10-28 | — | — | US | disclosed |
| US-6765021-B2 | ANTIDIABETIC AGENTS | WYETH | 2004-07-20 | — | — | US | disclosed |
| US-20030083341-A1 | 2,3,5-Substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2003-05-01 | — | — | US | disclosed |
| US-20010018525-A1 | 2, 3, 5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2001-08-30 | — | — | US | disclosed |
| US-6214877-B1 | ANTIDIABETIC AGENTS; MODULATOR OF GLUCOSE CONCENTRATION | WYETH | 2001-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083341-A1 | 2,3,5-Substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, IRS1 | TK2 1486/4885TK1 3656/4885 |
| US-20010018525-A1 | 2, 3, 5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, IRS1 | TK2 1484/4885TK1 3655/4885 |
| US-20040214869-A1 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, IRS1 | TK2 1486/4885TK1 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.