Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 3/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | PRKX | P51817 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13813947 | 0.90 | PRKACA (0.56) | ADAMTS5ADAMTS4RAB9ANPC1MME | |
| SCHEMBL2249098 | 0.90 | PRKACA (0.56) | ADAMTS5ADAMTS4RAB9ANPC1MME | |
| SCHEMBL2247423 | 0.90 | PRKACA (0.56) | ADAMTS5ADAMTS4RAB9ANPC1MME | |
| SCHEMBL8237305 | 0.81 | CA2 (0.66) | ADAMTS5ADAMTS4RAB9ANPC1HPGDS | |
| SCHEMBL2252322 | 0.81 | CA2 (0.66) | ADAMTS5ADAMTS4RAB9ANPC1HPGDS | |
| SCHEMBL12356355 | 0.79 | RAB9A (0.76) | ADAMTS5ADAMTS4RAB9ANPC1HPGDS | |
| SCHEMBL9603365 | 0.79 | TDP1 (0.50) | ADAMTS5ADAMTS4MMEMAPK1LMNA | |
| SCHEMBL2246054 | 0.78 | MMP12 (0.76) | ADAMTS5ADAMTS4RAB9ANPC1HPGDS | |
| SCHEMBL2245321 | 0.78 | MMP12 (0.76) | ADAMTS5ADAMTS4RAB9ANPC1HPGDS | |
| SCHEMBL2245050 | 0.77 | NPC1 (0.52) | ADAMTS5ADAMTS4RAB9ANPC1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |