Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.49 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10941783 | 0.84 | TDP1 (0.50) | TDP1LMNAHSD17B10CTRB1CTSG | |
| SCHEMBL10941795 | 0.84 | TDP1 (0.50) | TDP1LMNAHSD17B10CTRB1CTSG | |
| SCHEMBL16155818 | 0.81 | CA2 (0.56) | TDP1LMNAHSD17B10HPGDCA2 | |
| SCHEMBL16149959 | 0.81 | CA2 (0.56) | TDP1LMNAHSD17B10HPGDCA2 | |
| SCHEMBL5855561 | 0.81 | CA2 (0.56) | TDP1LMNAHSD17B10HPGDCA2 | |
| SCHEMBL27708342 | 0.79 | ADAMTS5 (0.54) | TDP1LMNAHSD17B10MMEADAMTS4 | |
| SCHEMBL5858324 | 0.78 | LMNA (0.54) | TDP1LMNAHSD17B10HPGDADAMTS4 | |
| SCHEMBL16155631 | 0.78 | LMNA (0.51) | TDP1LMNAHSD17B10HDAC3HDAC4 | |
| SCHEMBL22747924 | 0.77 | PRSS1 (0.59) | CTRB1CTSGTAS1R3TAS1R1 | |
| SCHEMBL165896 | 0.77 | PRSS1 (0.61) | CTRB1CTSGTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993005046-A1 | AMINODIESTERS OF RAPAMYCIN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-18 | — | — | WO | disclosed |
| US-5162333-A | Treating transplantation rejection, autoimmune diseases, antiinflammatory | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-10 | — | — | US | disclosed |