Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959356 | 0.76 | PTPN1 (0.43) | PTPN1CNR1BCHEACHECYSLTR2 | |
| SCHEMBL28003598 | 0.69 | HTR6 (0.50) | PTPN1CNR1BCHEACHE | |
| SCHEMBL6055979 | 0.69 | PTPN1 (0.49) | PTPN1CNR1BCHEACHECYSLTR2 | |
| SCHEMBL8158524 | 0.68 | PTPN1 (0.41) | PTPN1CNR1BCHEACHECYSLTR2 | |
| SCHEMBL22419040 | 0.67 | PTPN1 (0.43) | PTPN1CNR1 | |
| SCHEMBL8165940 | 0.66 | CNR1 (0.37) | PTPN1CNR1BCHEACHECYSLTR2 | |
| SCHEMBL8160512 | 0.66 | CNR1 (0.40) | PTPN1CNR1BCHEACHECYSLTR2 | |
| SCHEMBL19901173 | 0.66 | ACHE (0.39) | PTPN1CNR1BCHEACHE | |
| SCHEMBL29137599 | 0.66 | BCHE (0.39) | PTPN1BCHEACHECYSLTR2CYSLTR1 | |
| SCHEMBL27731533 | 0.66 | PTPN1 (0.42) | PTPN1CNR1LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850336-A | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMA CO LTD | 2013-01-02 | — | — | CN | disclosed |
| CN-102702182-A | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders | OTSUKA PHARMA CO LTD | 2012-10-03 | — | — | CN | disclosed |
| CN-102558140-A | Derivatives of 4-piperazin-1-1-yl-4-benzo [b] thiophene suitable for the treatment of cns disorders | OTSUKA PHARMA CO LTD | 2012-07-11 | — | — | CN | disclosed |
| CN-101258147-B | 4-piperazin-1-yl-4-benzo [ B ] thiophene derivatives for the treatment of CNS disorders | OTSUKA PHARMA CO LTD | 2012-03-21 | — | — | CN | disclosed |
| CN-101258147-A | 4-piperazin-1-yl-4-benzo [ B ] thiophene derivatives for the treatment of CNS disorders | OTSUKA PHARMA CO LTD (JP) | 2008-09-03 | — | — | CN | disclosed |