Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | DBH | P09172 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27711676 | 0.78 | — | — | |
| SCHEMBL27691694 | 0.77 | ADRB2 (0.39) | HSP90AA1HSP90AB1ADRB2ADRB1ADRB3 | |
| SCHEMBL27800576 | 0.74 | MEN1 (0.36) | HSP90AA1HSP90AB1PTGS1PTGS2MEN1 | |
| SCHEMBL27686304 | 0.73 | MAPK1 (0.35) | HSP90AA1HSP90AB1PTGS1PTGS2MEN1 | |
| SCHEMBL27831460 | 0.73 | PTGS1 (0.33) | HSP90AA1HSP90AB1PTGS1PTGS2KDM4E | |
| SCHEMBL27691525 | 0.73 | PTGS1 (0.33) | HSP90AA1HSP90AB1PTGS1PTGS2KDM4E | |
| SCHEMBL1829709 | 0.72 | GRM2 (0.41) | HSP90AA1HSP90AB1PIK3CAKDM4EDBH | |
| SCHEMBL28186848 | 0.72 | PDE2A (0.47) | HSP90AA1HSP90AB1PDE2AMEN1KMT2A | |
| SCHEMBL27689599 | 0.71 | ADRB2 (0.35) | ADRB2ADRB1ADRB3PTGS1PTGS2 | |
| SCHEMBL27846971 | 0.70 | PIM1 (0.36) | PIK3CAMEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-102099344-A | Imidazole carboxamides | LILLY CO ELI | 2011-06-15 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |