Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DBH | P09172 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800576 | 0.78 | MEN1 (0.36) | PTGS1HSP90AA1HSP90AB1PTGS2GABRA1 | |
| SCHEMBL27686304 | 0.77 | MAPK1 (0.35) | PTGS1HSP90AA1HSP90AB1PTGS2GABRA1 | |
| SCHEMBL27831460 | 0.77 | PTGS1 (0.33) | PTGS1HSP90AA1HSP90AB1PTGS2GABRA1 | |
| SCHEMBL27691694 | 0.77 | ADRB2 (0.39) | PTGS1HSP90AA1HSP90AB1PTGS2KDM4E | |
| SCHEMBL27691527 | 0.76 | ERN1 (0.32) | GABRA1GABRB1GABRB2RNASEH1TYR | |
| SCHEMBL27711675 | 0.73 | HSP90AA1 (0.33) | PTGS1HSP90AA1HSP90AB1PTGS2KDM4E | |
| SCHEMBL27609913 | 0.72 | CA1 (0.46) | PTGS1GABRA1GABRB1GABRB2KDM4E | |
| SCHEMBL27705273 | 0.72 | PDE4A (0.41) | PTGS1PTGS2GABRA1GABRB1KDM4E | |
| SCHEMBL27641334 | 0.72 | PRKCI (0.39) | HSP90AA1HSP90AB1KDM4EFFAR1HPGD | |
| SCHEMBL1827944 | 0.69 | GAA (0.44) | HSP90AA1HSP90AB1KDM4EDBHGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-102099344-A | Imidazole carboxamides | LILLY CO ELI | 2011-06-15 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |