Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DBH | P09172 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249192 | 0.79 | GABRA1 (0.50) | ADRB2ADRB1ADRB3ADRA2AADRA2B | |
| SCHEMBL27689599 | 0.79 | ADRB2 (0.35) | ADRB2ADRB1ADRB3ADRA2AADRA2B | |
| SCHEMBL27800576 | 0.78 | MEN1 (0.36) | ADRA1AHSP90AA1HSP90AB1PTGS1PTGS2 | |
| SCHEMBL27686304 | 0.77 | MAPK1 (0.35) | ADRA1AHSP90AA1HSP90AB1PTGS1PTGS2 | |
| SCHEMBL27691525 | 0.77 | PTGS1 (0.33) | ADRA1AHSP90AA1HSP90AB1PTGS1PTGS2 | |
| SCHEMBL27831460 | 0.77 | PTGS1 (0.33) | ADRA1AHSP90AA1HSP90AB1PTGS1PTGS2 | |
| SCHEMBL27842026 | 0.77 | ADRB1 (0.49) | ADRB1ADRB3ADRA2AADRA2BADRA2C | |
| SCHEMBL27711675 | 0.77 | HSP90AA1 (0.33) | ADRB2ADRB1ADRB3HSP90AA1HSP90AB1 | |
| SCHEMBL27691695 | 0.76 | ADRB2 (0.38) | ADRB2ADRB1ADRB3ADRA2AADRA2B | |
| SCHEMBL27520331 | 0.73 | PTGS1 (0.42) | HSP90AA1HSP90AB1PTGS1PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |