Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545527 | 0.76 | TTK (0.48) | AKR1B1HTR6METABCB1ABCC1 | |
| SCHEMBL13721413 | 0.74 | ATM (0.51) | AKR1B1HTR6ALDH1A1MAPTKDM4E | |
| SCHEMBL3531032 | 0.70 | FFAR2 (0.40) | AKR1B1HTR6METABCB1ABCC1 | |
| Piperazine SCHEMBL1544743 | 0.70 | TTK (0.43) | AKR1B1HTR6TP53RAB9AALDH1A1 | |
| SCHEMBL2564745 | 0.68 | PDPK1 (0.47) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL135237 | 0.66 | CYP1A2 (0.39) | LMNA | |
| SCHEMBL2018265 | 0.65 | KDM4E (0.38) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL6977741 | 0.65 | IDO1 (0.52) | AKR1B1KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3955838 | 0.64 | HTR6 (0.48) | HTR6KMT2AMEN1ALDH1A1PIK3CA | |
| SCHEMBL2299132 | 0.64 | KIF11 (0.44) | AKR1B1HTR6ABCB1ABCC1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101282938-A | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH CORP (US) | 2008-10-08 | — | — | CN | claimed |
| CN-101282938-A | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH CORP (US) | 2008-10-08 | — | — | CN | disclosed |