Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771920 | 0.80 | — | — | |
| SCHEMBL13116022 | 0.75 | NOS3 (0.61) | NOS3NOS2S1PR2KDM4EPOLB | |
| SCHEMBL30689573 | 0.75 | NOS3 (0.61) | NOS3NOS2S1PR2KDM4EPOLB | |
| SCHEMBL18689678 | 0.74 | ALDH1A1 (0.43) | NOS3NOS2S1PR2KMT2AKDM4E | |
| SCHEMBL2771689 | 0.73 | NOS3 (0.35) | NOS3NOS2S1PR2MEN1KMT2A | |
| SCHEMBL165100 | 0.71 | — | — | |
| SCHEMBL16454931 | 0.71 | PGK1 (0.38) | NOS3NOS2S1PR2KMT2A | |
| SCHEMBL19225767 | 0.71 | TRPM8 (0.42) | NOS3NOS2S1PR2MEN1KMT2A | |
| SCHEMBL2770494 | 0.68 | ALDH1A1 (0.44) | MEN1KMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL18153309 | 0.68 | MAPT (0.50) | MEN1KMT2AKDM4ENPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181112-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | Merck Serono S.A. (CH) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009027283-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO S.A. (CH) | 2009-03-05 | — | — | WO | disclosed |