Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720178 | 0.89 | RAB9A (0.60) | MEN1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL27720117 | 0.87 | BRAF (0.61) | MEN1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL27720129 | 0.86 | MEN1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27720155 | 0.85 | BRAF (0.64) | SMN1; SMN2MAPTRAB9ANPC1RAF1 | |
| SCHEMBL27720144 | 0.85 | TP53 (0.62) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27720100 | 0.82 | BRAF (0.63) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27740983 | 0.81 | CDK8 (0.56) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL27720191 | 0.80 | CDK8 (0.55) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27720157 | 0.79 | MAPT (0.64) | MEN1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL617631 | 0.76 | RAF1 (0.65) | MEN1KMT2ASMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |