Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 3/20 | 0.61 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | STAT1 | P42224 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720117 | 0.91 | BRAF (0.61) | TP53TSHRRAF1RAB9ANPC1 | |
| SCHEMBL27740983 | 0.89 | CDK8 (0.56) | RAF1CDK8RAB9ANPC1MAPT | |
| SCHEMBL27720191 | 0.88 | CDK8 (0.55) | TP53TSHRRAF1CDK8RAB9A | |
| SCHEMBL27720155 | 0.87 | BRAF (0.64) | RAF1CDK8RAB9ANPC1MAPT | |
| SCHEMBL27720107 | 0.85 | MEN1 (0.61) | TSHRRAF1RAB9ANPC1MAPT | |
| SCHEMBL27720100 | 0.84 | BRAF (0.63) | RAF1CDK8RAB9ANPC1MAPT | |
| SCHEMBL27720157 | 0.83 | MAPT (0.64) | RAF1CDK8RAB9ANPC1MAPT | |
| SCHEMBL27720178 | 0.82 | RAB9A (0.60) | RAF1CDK8RAB9ANPC1MAPT | |
| SCHEMBL21295338 | 0.81 | TP53 (0.83) | TP53TSHRRAF1CDK8RAB9A | |
| SCHEMBL29526156 | 0.80 | RIPK1 (0.61) | TP53TSHRRAF1CDK8RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |