Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932898 | 0.89 | BRAF (0.59) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3940458 | 0.78 | BRAF (0.63) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3943800 | 0.78 | BRAF (0.80) | BRAFCSF1RCYP11B2SMN1; SMN2 | |
| SCHEMBL3934814 | 0.77 | BRAF (0.62) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3935960 | 0.77 | BRAF (0.68) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL27720411 | 0.76 | CYP11B2 (0.76) | BRAFCSF1RCYP11B2MEN1KMT2A | |
| SCHEMBL3933131 | 0.76 | BRAF (0.71) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3942168 | 0.76 | IDO1 (0.77) | BRAFCSF1RLMNANPC1RAB9A | |
| SCHEMBL3934829 | 0.76 | BRAF (0.83) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3932944 | 0.76 | BRAF (0.82) | BRAFCSF1RKITKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |