Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TLR4 | O00206 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL5959955 | 0.88 | ALDH1A1 (0.67) | TSHRALDH1A1LMNATP53MAPK1 | |
| Styrene SCHEMBL165374 | 0.88 | ALDH1A1 (0.67) | TSHRALDH1A1LMNATP53MAPK1 | |
| Diphenylether SCHEMBL27555034 | 0.87 | TSHR (0.54) | TSHRALDH1A1SOS1LTA4HLMNA | |
| Diphenylether SCHEMBL787546 | 0.86 | TSHR (0.70) | TSHRALDH1A1SOS1LTA4HPPARG | |
| Diphenylether SCHEMBL27969627 | 0.85 | TSHR (0.52) | TSHRALDH1A1SOS1LTA4HLMNA | |
| Diphenylether SCHEMBL28161775 | 0.85 | TSHR (0.52) | TSHRALDH1A1SOS1LTA4HLMNA | |
| Diphenylether SCHEMBL22806499 | 0.85 | TSHR (0.52) | TSHRALDH1A1SOS1LTA4HLMNA | |
| Diphenylether SCHEMBL27969630 | 0.85 | TSHR (0.52) | TSHRALDH1A1SOS1LTA4HLMNA | |
| Styrene SCHEMBL4274364 | 0.84 | ALDH1A1 (0.67) | TSHRALDH1A1LMNATP53MAPK1 | |
| Styrene SCHEMBL15313172 | 0.84 | ALDH1A1 (0.67) | TSHRALDH1A1LMNATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101305025-B | Acrylic polymer beads and sol composition containing the same | KOLON INC | 2011-03-30 | — | — | CN | disclosed |
| CN-101305025-A | Acrylic polymer beads and sol composition containing the same | KOLON INC (KR) | 2008-11-12 | — | — | CN | disclosed |