Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.53 |
| ▸ | SCD | O00767 | 4/20 | 0.53 |
| ▸ | NPY2R | P49146 | 2/20 | 0.53 |
| ▸ | GBA1 | P04062 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973493 | 0.76 | SCD (0.55) | SCDNPY2RGBA1LMNATSHR | |
| SCHEMBL5371899 | 0.76 | SCD (0.52) | SCDNPY2RGBA1TSHRSMN1; SMN2 | |
| SCHEMBL13983799 | 0.76 | SCD (0.62) | P2RX7SCDNPY2RGBA1L3MBTL1 | |
| SCHEMBL3312656 | 0.76 | ALDH1A1 (0.72) | KDM4ELMNAGLAGAAL3MBTL1 | |
| SCHEMBL31011166 | 0.75 | ALDH1A1 (0.67) | P2RX7KDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL4262448 | 0.74 | CYP2C9 (0.63) | SCDNPY2RGBA1TSHR | |
| SCHEMBL3455972 | 0.73 | LMNA (0.73) | KDM4ELMNAGLAGAAL3MBTL1 | |
| SCHEMBL2820604 | 0.73 | SCD (0.58) | P2RX7SCDNPY2RGBA1 | |
| SCHEMBL13282314 | 0.73 | SCD (0.56) | P2RX7SCDNPY2RGBA1 | |
| SCHEMBL4716887 | 0.73 | SCD (0.56) | SCDNPY2RGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163504-A | Combination therapy | XENON PHARMACEUTICALS INC (CA) | 2008-04-16 | — | — | CN | claimed |
| CN-101980709-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-02-23 | — | — | CN | disclosed |
| CN-101669952-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-03-17 | — | — | CN | disclosed |
| CN-101163504-A | Combination therapy | XENON PHARMACEUTICALS INC (CA) | 2008-04-16 | — | — | CN | disclosed |