Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 8/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975638 | 0.86 | MAPT (0.53) | SCDMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2466841 | 0.81 | SCD (0.61) | SCDMAPK1USP2SMN1; SMN2GBA1 | |
| SCHEMBL4910844 | 0.78 | SCD (0.57) | SCDMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL1842256 | 0.78 | LMNA (0.62) | MAPK1MEN1KMT2AUSP2SMN1; SMN2 | |
| SCHEMBL27657963 | 0.78 | SCD (0.60) | SCDMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL5822275 | 0.78 | SCD (0.52) | SCDMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL5821738 | 0.77 | SCD (0.49) | SCDMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL2466840 | 0.77 | SCD (0.67) | SCD | |
| SCHEMBL27722326 | 0.76 | P2RX7 (0.53) | SCDSMN1; SMN2GBA1NPY2RTSHR | |
| SCHEMBL5821442 | 0.76 | MAPK1 (0.55) | SCDMAPK1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009414-A9 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2011-01-13 | — | — | US | disclosed |
| US-20090291957-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2009-11-26 | — | — | US | disclosed |
| US-7547698-B2 | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD) | XENON PHARMACEUTICALS INC. (CA) | 2009-06-16 | — | — | US | disclosed |
| US-20070219211-A1 | Bicyclic Heterocyclic Derivatives and Their Use as Inhibitors of Stearoyl-Coadesaturase (Scd) | XENON PHARMACEUTICALS INC. (CA) | 2007-09-20 | — | — | US | disclosed |
| EP-1804792-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF STEAROYL-COA-DESATURASE (SCD) | XENON PHARMACEUTICALS INC. (CA) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006034312-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF STEAROYL-COA-DESATURASE (SCD) | XENON PHARMACEUTICALS INC. (CA) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009414-A9 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | CCNY, SNRPD2, SNRPD3 | SCD 10/4885MAPK1 4102/4885MEN1 3195/4885 |
| US-20090291957-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | CCNY, SNRPD2, SNRPD3 | SCD 10/4885MAPK1 4102/4885MEN1 3195/4885 |
| US-20070219211-A1 | Bicyclic Heterocyclic Derivatives and Their Use as Inhibitors of Stearoyl-Coadesaturase (Scd) | SCD, SCD5, ECHS1 | SCD 1/4885MAPK1 4495/4885MEN1 4613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.