Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703399 | 0.88 | CES1 (0.56) | CES1ALDH1A1AGTR1ALDH2ALDH3A1 | |
| SCHEMBL3678891 | 0.83 | ALDH1A1 (0.50) | CES1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL25707100 | 0.82 | CES1 (0.50) | CES1ALDH1A1AGTR1TTRBCHE | |
| SCHEMBL28476821 | 0.82 | ALDH1A1 (0.55) | CES1ALDH1A1AGTR1KMT2AMEN1 | |
| SCHEMBL27703278 | 0.81 | ALDH3A1 (0.43) | CES1ALDH1A1AGTR1ALDH2ALDH3A1 | |
| SCHEMBL25706975 | 0.81 | CES1 (0.46) | CES1ALDH1A1AGTR1ALDH2ALDH3A1 | |
| SCHEMBL10800205 | 0.80 | CES1 (0.57) | CES1ALDH1A1AGTR1ALDH2ALDH3A1 | |
| SCHEMBL13725997 | 0.79 | CES1 (0.51) | CES1ALDH1A1AGTR1ALDH2ALDH3A1 | |
| SCHEMBL27839876 | 0.78 | CES1 (0.56) | CES1ALDH1A1AGTR1ALDH2ALDH3A1 | |
| SCHEMBL27703282 | 0.78 | CES1 (0.38) | CES1ALDH1A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103271906-A | Use of spiro-oxindole compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2013-09-04 | — | — | CN | disclosed |
| CN-102153562-A | Spiro-oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-08-17 | — | — | CN | disclosed |
| CN-101631546-A | Use of spiro-indolone compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-01-20 | — | — | CN | disclosed |
| CN-101213174-A | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-07-02 | — | — | CN | disclosed |
| CN-101184761-A | Spiro-indolone compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-05-21 | — | — | CN | disclosed |