Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 6/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703402 | 0.84 | CES1 (0.38) | CES1ELANEALDH1A1 | |
| SCHEMBL27723886 | 0.78 | CES1 (0.58) | CES1TGM2ALDH1A1 | |
| SCHEMBL27703278 | 0.74 | ALDH3A1 (0.43) | CES1ALDH1A1 | |
| SCHEMBL27703281 | 0.71 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL9106961 | 0.70 | POLB (0.54) | ALDH1A1 | |
| SCHEMBL28476821 | 0.69 | ALDH1A1 (0.55) | CES1ALDH1A1 | |
| SCHEMBL3678891 | 0.69 | ALDH1A1 (0.50) | CES1ALDH1A1 | |
| SCHEMBL28138059 | 0.69 | L3MBTL1 (0.48) | TGM2IDO1TDO2IDO2ALDH1A1 | |
| SCHEMBL754994 | 0.67 | CES1 (0.50) | CES1TGM2IDO1TDO2IDO2 | |
| SCHEMBL24169113 | 0.67 | TDP1 (0.58) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103271906-A | Use of spiro-oxindole compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2013-09-04 | — | — | CN | disclosed |
| CN-102153562-A | Spiro-oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-08-17 | — | — | CN | disclosed |
| CN-101631546-A | Use of spiro-indolone compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-01-20 | — | — | CN | disclosed |
| CN-101213174-A | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-07-02 | — | — | CN | disclosed |
| CN-101184761-A | Spiro-indolone compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-05-21 | — | — | CN | disclosed |