Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.43 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28476821 | 0.85 | ALDH1A1 (0.55) | ALDH1A1CES1AGTR1 | |
| SCHEMBL27723886 | 0.81 | CES1 (0.58) | ALDH3A1ALDH1A1ALDH2CES1AGTR1 | |
| SCHEMBL27703282 | 0.74 | CES1 (0.38) | ALDH1A1CES1 | |
| SCHEMBL10568960 | 0.71 | ALDH1A1 (0.48) | ALDH3A1ALDH1A1ALDH2GABRA1GABRG2 | |
| SCHEMBL27703276 | 0.71 | ALDH1A1 (0.76) | ALDH3A1ALDH1A1ALDH2TSHR | |
| SCHEMBL2373229 | 0.71 | CES1 (0.63) | ALDH3A1ALDH1A1ALDH2CES1AGTR1 | |
| SCHEMBL11959135 | 0.70 | ALDH1A1 (0.56) | ALDH3A1ALDH1A1ALDH2CES1AGTR1 | |
| SCHEMBL18954676 | 0.70 | ALDH1A1 (0.56) | ALDH3A1ALDH1A1ALDH2GABRA1GABRG2 | |
| SCHEMBL16048101 | 0.70 | ALDH3A1 (0.65) | ALDH3A1ALDH1A1ALDH2 | |
| SCHEMBL11369567 | 0.70 | S100A4 (0.47) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103271906-A | Use of spiro-oxindole compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2013-09-04 | — | — | CN | disclosed |
| CN-102153562-A | Spiro-oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-08-17 | — | — | CN | disclosed |
| CN-101631546-A | Use of spiro-indolone compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-01-20 | — | — | CN | disclosed |
| CN-101213174-A | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-07-02 | — | — | CN | disclosed |
| CN-101184761-A | Spiro-indolone compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-05-21 | — | — | CN | disclosed |