Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | SNCA | P37840 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709644 | 0.76 | HDAC8 (0.39) | BRD4HDAC8HDAC6 | |
| SCHEMBL8391241 | 0.74 | BACE1 (0.49) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL3222973 | 0.74 | APP (0.64) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL8389135 | 0.73 | APP (0.50) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL11352221 | 0.73 | UGT2B7 (0.42) | — | |
| SCHEMBL8389114 | 0.71 | APP (0.45) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL858 | 0.71 | CYP2D6 (0.42) | HTR6 | |
| SCHEMBL28101302 | 0.70 | HTR6 (0.60) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL28784163 | 0.70 | ALDH1A1 (0.41) | — | |
| SCHEMBL5134071 | 0.69 | HTR6 (0.66) | HTR6APPSNCABRD4BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101321726-A | Novel fused pyrrole derivative | DAINIPPON SUMITOMO PHARMA CO (JP) | 2008-12-10 | — | — | CN | disclosed |