Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27656709 | 0.97 | TSHR (0.40) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Pyrrolidine SCHEMBL3839669 | 0.86 | ALDH1A1 (0.40) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL6046913 | 0.86 | TSHR (0.32) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperidine SCHEMBL30496139 | 0.84 | ALDH1A1 (0.45) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Piperidine SCHEMBL28253499 | 0.84 | ALDH1A1 (0.45) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Ammonia Solution, Strong SCHEMBL60731 | 0.82 | — | — | |
| Ammonia Solution, Strong SCHEMBL30658910 | 0.82 | TSHR (0.47) | TSHRCA2USP2CA1TDP1 | |
| Ammonia Solution, Strong SCHEMBL7529876 | 0.82 | — | — | |
| Ammonia Solution, Strong SCHEMBL7529877 | 0.82 | TSHR (0.47) | TSHRCA2USP2CA1TDP1 | |
| Morpholine SCHEMBL9984285 | 0.80 | MEN1 (0.48) | TSHRLMNACYP3A4GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102225046-A | Transdermal drug delivery formulation | NUVO RES INC | 2011-10-26 | — | — | CN | disclosed |
| CN-101296691-B | Transdermal drug delivery dosage form | NUVO RES INC | 2011-07-27 | — | — | CN | disclosed |
| CN-101296691-A | transdermal drug delivery dosage form | NUVO RES INC (CA) | 2008-10-29 | — | — | CN | disclosed |