Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910139 | 0.77 | PTGS1 (0.43) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL5850523 | 0.76 | PTGS1 (0.47) | PTGS1PTGS2SLC22A12TSHRSMN1; SMN2 | |
| SCHEMBL460510 | 0.73 | ALOX15 (0.50) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL27664892 | 0.73 | ALOX15 (0.50) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL20569781 | 0.73 | PTGS2 (0.39) | PTGS1PTGS2SLC22A12TSHRSMN1; SMN2 | |
| SCHEMBL11708959 | 0.72 | KMT2A (0.52) | TSHRSMN1; SMN2ALDH1A1HPGDPDE10A | |
| Hydrochloric Acid SCHEMBL4703144 | 0.71 | ALOX15 (0.48) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL30021764 | 0.71 | ALOX15 (0.48) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL14525924 | 0.69 | ALDH1A1 (0.50) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL14525863 | 0.69 | ALDH1A1 (0.50) | PTGS1PTGS2SLC22A12SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189028-B | Identification and engineering of antibodies with variant Fc regions and methods of use | MACROGENICS INC | 2013-05-29 | — | — | CN | disclosed |
| CN-101189028-A | Identification and engineering of antibodies with variant Fc regions and methods of use | MACROGENICS INC (US) | 2008-05-28 | — | — | CN | disclosed |