Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | GLA | P06280 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL27479824 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL9106792 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL31425247 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL27479825 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL28796207 | 0.98 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL28471035 | 0.87 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Nitric Acid SCHEMBL3888889 | 0.84 | KMT2A (0.51) | ALDH1A1HPGDMAPTGLAACHE | |
| Anthracene SCHEMBL27489981 | 0.84 | CYP3A4 (0.54) | ALDH1A1HPGDGLARAB9AKMT2A | |
| Acridine SCHEMBL27545385 | 0.83 | RAB9A (0.63) | ALDH1A1HPGDMAPTGLAACHE | |
| Nitric Acid SCHEMBL3961222 | 0.81 | KMT2A (0.49) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114391095-A | Oxidase-based chemiluminescence assay of phagocytic leukocytes in whole blood and body fluids suitable for point-of-care (POC) measurement of Absolute Neutrophil Function (ANF) for point-of-care (POC) diagnostic tests | 比纳瑞有限责任公司 | 2022-04-22 | — | — | CN | claimed |
| CN-108350466-B | Methods and compositions for determining pH | 芝加哥大学 | 2022-06-24 | — | — | CN | disclosed |
| CN-114391095-A | Oxidase-based chemiluminescence assay of phagocytic leukocytes in whole blood and body fluids suitable for point-of-care (POC) measurement of Absolute Neutrophil Function (ANF) for point-of-care (POC) diagnostic tests | 比纳瑞有限责任公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-114391095-A | Oxidase-based chemiluminescence assay of phagocytic leukocytes in whole blood and body fluids suitable for point-of-care (POC) measurement of Absolute Neutrophil Function (ANF) for point-of-care (POC) diagnostic tests | 比纳瑞有限责任公司 | 2022-04-22 | — | — | CN | disclosed |
| EP-1549759-B1 | BACTERIAL TEST METHOD BY GLYCATED INTRACELLULAR ENZYMES | SIEMENS HEALTHCARE DIAGNOSTICS (US) | 2010-04-28 | — | — | EP | disclosed |
| EP-1549759-A4 | BACTERIAL TEST METHOD BY GLYCATED LABEL BINDING | BAYER HEALTHCARE LLC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20060141546-A1 | Bacterial test method by glycated label binding | SIEMENS HEALTHCARE DIAGNOSTICS INC. | 2006-06-29 | — | — | US | disclosed |
| EP-1549759-A1 | BACTERIAL TEST METHOD BY GLYCATED LABEL BINDING | Bayer Healthcare LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2003106699-A1 | BACTERIAL TEST METHOD BY GLYCATED LABEL BINDING | BAYER HEALTHCARE LLC (US) | 2003-12-24 | — | — | WO | disclosed |
| US-20030232401-A1 | Bacterial test method by glycated label binding | BAYER CORPORATION | 2003-12-18 | — | — | US | disclosed |
| EP-0660876-A1 | A PROCESS OF QUANTIFYING CELL NUMBER | Packard Instrument Company, Inc. (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5306624-A | Process of quantifying cell number | PACKARD INSTRUMENT CO., INC. (US) | 1994-04-26 | — | — | US | disclosed |
| WO-1994006932-A1 | A PROCESS OF QUANTIFYING CELL NUMBER | PACKARD INSTRUMENT COMPANY, INC. (US) | 1994-03-31 | — | — | WO | disclosed |