Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | GLA | P06280 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL27479824 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL2772852 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL31425247 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL27479825 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL28796207 | 0.98 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL28471035 | 0.87 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Nitric Acid SCHEMBL3888889 | 0.84 | KMT2A (0.51) | ALDH1A1HPGDMAPTGLAACHE | |
| Anthracene SCHEMBL27489981 | 0.84 | CYP3A4 (0.54) | ALDH1A1HPGDGLARAB9AKMT2A | |
| Acridine SCHEMBL27545385 | 0.83 | RAB9A (0.63) | ALDH1A1HPGDMAPTGLAACHE | |
| Nitric Acid SCHEMBL3961222 | 0.81 | KMT2A (0.49) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11248048-B2 | Antibody to programmed cell death 1 (PD-1) and use thereof | Y-Biologics Inc. (KR) | 2022-02-15 | — | — | US | disclosed |
| US-10919966-B2 | Antibody to programmed death-ligand 1 (PD-L1) and use thereof | Y-Biologics Inc. (KR) | 2021-02-16 | — | — | US | disclosed |
| US-20190322750-A1 | ANTIBODY TO PROGRAMMED CELL DEATH-LIGAND 1 (PD-L1) AND USE THEREOF | Y-Biologics Inc. (KR) | 2019-10-24 | — | — | US | disclosed |
| US-20190248900-A1 | ANTIBODY TO PROGRAMMED CELL DEATH 1 (PD-1) AND USE THEREOF | Y-Biologics Inc. (KR) | 2019-08-15 | — | — | US | disclosed |
| EP-3495391-A1 | ANTIBODY AGAINST PROGRAMMED DEATH-LIGAND 1 (PD-L1), AND USE THEREOF | Y-Biologics Inc. (KR) | 2019-06-12 | — | — | EP | disclosed |
| EP-3495390-A1 | NOVEL ANTIBODY AGAINST PROGRAMMED CELL DEATH PROTEIN (PD-1), AND USE THEREOF | Y-Biologics Inc. (KR) | 2019-06-12 | — | — | EP | disclosed |
| EP-0527186-A4 | — | UNIV ILLINOIS (US) | 1995-01-18 | — | — | EP | disclosed |
| US-5242892-A | With 5-aminolevulinic acid | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0527186-A1 | PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS | The Board of Trustees for the University of Illinois (US) | 1993-02-17 | — | — | EP | disclosed |
| WO-1991016820-A1 | PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1991-11-14 | — | — | WO | disclosed |