Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL27968557 | 1.00 | KMT2A (0.49) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL29376451 | 0.87 | ALDH1A1 (0.60) | KMT2ARAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL291182 | 0.87 | ALDH1A1 (0.60) | KMT2ARAB9AALDH1A1KDM4EHPGD | |
| Nitric Acid SCHEMBL2290191 | 0.85 | KDM4E (0.40) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| Nitric Acid SCHEMBL27944104 | 0.85 | KDM4E (0.48) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| Nitric Acid SCHEMBL9696991 | 0.85 | KDM4E (0.48) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL28881738 | 0.85 | ALDH1A1 (0.58) | KMT2ARAB9AALDH1A1KDM4EHPGD | |
| Nitric Acid SCHEMBL3888889 | 0.84 | KMT2A (0.51) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL5854489 | 0.83 | ALDH1A1 (0.53) | KMT2ARAB9AALDH1A1KDM4EHPGD | |
| Acridine SCHEMBL31425247 | 0.81 | ALDH1A1 (0.65) | KMT2AMEN1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9835621-B2 | Process for detection of alzheimer's disease from a serum sample | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-12-05 | — | — | US | disclosed |
| US-20140302535-A1 | PROCESS FOR DETECTION OF ALZHEIMER'S DISEASE FROM A SERUM SAMPLE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2014-10-09 | — | — | US | disclosed |
| EP-2702397-A2 | METHOD AND APPARATUS FOR DETERMINATION OF SYSTEM PARAMETERS FOR REDUCING CRUDE UNIT CORROSION | Nalco Company (US) | 2014-03-05 | — | — | EP | disclosed |
| EP-2688565-A1 | TREATMENT OF PROLIFERATIVE DISORDERS WITH A CHEMILUMINESCENT AGENT | Semorex Technologies Ltd. (IL) | 2014-01-29 | — | — | EP | disclosed |
| EP-2646806-A2 | METHOD AND APPARATUS FOR DETERMINATION OF SYSTEM PARAMETERS FOR REDUCING CRUDE UNIT CORROSION | Nalco Company (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012149076-A2 | METHOD AND APPARATUS FOR DETERMINATION OF SYSTEM PARAMETERS FOR REDUCING CRUDE UNIT CORROSION | NALCO COMPANY (US) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012127441-A1 | TREATMENT OF PROLIFERATIVE DISORDERS WITH A CHEMILUMINESCENT AGENT | SEMOREX TECHNOLOGIES LTD. (IL) | 2012-09-27 | — | — | WO | disclosed |
| WO-2012075076-A2 | METHOD AND APPARATUS FOR DETERMINATION OF SYSTEM PARAMETERS FOR REDUCING CRUDE UNIT CORROSION | NALCO COMPANY (US) | 2012-06-07 | — | — | WO | disclosed |
| US-20090131361-A1 | Novel Use of MLN51 Gene and Protein | CREAGENE INC. (KP) | 2009-05-21 | — | — | US | disclosed |
| WO-2009038288-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CATARACT | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2009-03-26 | — | — | WO | disclosed |
| US-20020022218-A1 | Methods for the identification of compounds useful for the treatment of disease states medicated by prostaglandin D2 | PFIZER INC. | 2002-02-21 | — | — | US | disclosed |
| EP-1170594-A2 | Methods for the identification of compounds useful for the treatment of disease states mediated by Prostaglandin D2 | Pfizer Products Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2001087957-A2 | NOVEL DUAL OXIDASES AS MITOGENIC AND ENDOCRINE REGULATORS | EMORY UNIVERSITY (US) | 2001-11-22 | — | — | WO | disclosed |
| EP-1131430-A2 | MITOGENIC REGULATORS | Emory University (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000028031-A2 | MITOGENIC REGULATORS | EMORY UNIVERSITY (US) | 2000-05-18 | — | — | WO | disclosed |
| EP-0815166-A4 | PROCESS FOR PREPARING POLYVINYLBUTYRAL SHEET | DU PONT (US) | 1998-06-10 | — | — | EP | disclosed |
| EP-0815166-A1 | PROCESS FOR PREPARING POLYVINYLBUTYRAL SHEET | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028504-A1 | PROCESS FOR PREPARING POLYVINYLBUTYRAL SHEET | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-09-19 | — | — | WO | disclosed |
| EP-0660876-A1 | A PROCESS OF QUANTIFYING CELL NUMBER | Packard Instrument Company, Inc. (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006932-A1 | A PROCESS OF QUANTIFYING CELL NUMBER | PACKARD INSTRUMENT COMPANY, INC. (US) | 1994-03-31 | — | — | WO | disclosed |