Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751837 | 0.86 | CYP19A1 (0.41) | LMNAALDH1A1TDP1SMN1; SMN2CYP19A1 | |
| SCHEMBL27919840 | 0.83 | CYP19A1 (0.46) | ALDH1A1CYP19A1KDM4E | |
| SCHEMBL27697283 | 0.82 | THRB (0.45) | LMNAALDH1A1TDP1SMN1; SMN2CYP19A1 | |
| SCHEMBL27749453 | 0.80 | HRH2 (0.37) | LMNAALDH1A1TDP1SMN1; SMN2CYP19A1 | |
| SCHEMBL27697291 | 0.78 | PARP1 (0.49) | LMNAALDH1A1TDP1SMN1; SMN2CYP19A1 | |
| SCHEMBL27489308 | 0.77 | KDM4E (0.55) | ALDH1A1CYP19A1MEN1KMT2APOLB | |
| SCHEMBL27782147 | 0.72 | EGFR (0.42) | LMNAALDH1A1CYP19A1GAAKDM4E | |
| SCHEMBL28778083 | 0.72 | PDE4A (0.42) | CYP19A1 | |
| SCHEMBL27757478 | 0.72 | ALDH1A1 (0.35) | LMNAALDH1A1TDP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL27418241 | 0.72 | CYP19A1 (0.43) | LMNAALDH1A1CYP19A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511819-B | Derivatives of N- (amino-heteroaryl) -1H-indole-2-amides, preparation thereof and use thereof in therapy | SANOFI AVENTIS | 2014-04-23 | — | — | CN | disclosed |
| CN-101379041-B | Tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole structural element, their preparation and their therapeutic use | SANOFI AVENTIS | 2012-08-29 | — | — | CN | disclosed |
| CN-101010297-B | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS | 2011-07-27 | — | — | CN | disclosed |
| CN-101379041-A | Tricyclic N-heteroaryl-amide derivatives containing benzimidazole structural units, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2009-03-04 | — | — | CN | disclosed |
| CN-101010297-A | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS (FR) | 2007-08-01 | — | — | CN | disclosed |