Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28778083 | 0.78 | PDE4A (0.42) | ICMTPTGS2CYP19A1 | |
| SCHEMBL27657202 | 0.78 | HTR6 (0.48) | PARP1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8686733 | 0.78 | ALDH1A1 (0.71) | PARP1LMNAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27729418 | 0.78 | LMNA (0.52) | LMNAALDH1A1SMN1; SMN2TDP1POLB | |
| SCHEMBL27677333 | 0.74 | ALDH1A1 (0.61) | LMNAALDH1A1SMN1; SMN2MAPTUSP2 | |
| SCHEMBL28774047 | 0.74 | PARP1 (0.52) | PARP1LMNAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL9585401 | 0.73 | MEN1 (0.50) | PARP1ALDH1A1ICMTADAM17USP2 | |
| Ethoxycarbonyl Group SCHEMBL27598008 | 0.73 | PARP1 (0.58) | PARP1LMNAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27597889 | 0.73 | MAPT (0.47) | LMNAALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL4354844 | 0.73 | ICMT (0.54) | PARP1LMNAALDH1A1SMN1; SMN2ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101010297-B | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS | 2011-07-27 | — | — | CN | disclosed |
| CN-101010297-A | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS (FR) | 2007-08-01 | — | — | CN | disclosed |