Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.72 |
| ▸ | USP2 | O75604 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731981 | 0.85 | MAPT (0.59) | MAPTUSP2MAPK1TP53HSD17B10 | |
| SCHEMBL27711760 | 0.84 | MAPT (0.52) | MAPTUSP2MAPK1TP53HSD17B10 | |
| SCHEMBL27731980 | 0.82 | DGAT1 (0.51) | MAPTUSP2MAPK1TP53HSD17B10 | |
| SCHEMBL27732014 | 0.80 | MAPT (0.51) | MAPTUSP2MAPK1TP53HSD17B10 | |
| SCHEMBL27732009 | 0.79 | HTT (0.58) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL4491756 | 0.79 | MAPT (0.75) | MAPTUSP2MAPK1TP53HSD17B10 | |
| SCHEMBL27731978 | 0.79 | MAPT (0.54) | MAPTALDH1A1LMNACYP2C9HPGD | |
| SCHEMBL27711764 | 0.77 | MAPT (0.58) | MAPTUSP2MAPK1HSD17B10ALDH1A1 | |
| SCHEMBL27731982 | 0.75 | MAPT (0.57) | MAPTALDH1A1CYP2C19RAB9ANPC1 | |
| SCHEMBL270845 | 0.75 | MAPT (0.74) | MAPTUSP2MAPK1TP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243058-A | * oxadiazole derivatives as DGAT inhibitors | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | claimed |
| CN-101243058-A | * oxadiazole derivatives as DGAT inhibitors | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | disclosed |