Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.33 |
| ▸ | FABP1 | P07148 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ATP4A | P20648 | 1/20 | 0.32 |
| ▸ | ATP4B | P51164 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550501 | 0.68 | HSD11B1 (0.34) | MAPK14HSP90AB1HSD11B1PARP1 | |
| SCHEMBL21463762 | 0.68 | CD44 (0.45) | MAPK14BACE1KDM4EFABP1KCNA5 | |
| SCHEMBL15856465 | 0.68 | CA12 (0.51) | KDM4EFABP1DHFRKCNA5 | |
| SCHEMBL14039912 | 0.68 | PDE3B (0.44) | HSP90AB1KCNA5TLR8ACHE | |
| SCHEMBL3756908 | 0.67 | S1PR1 (0.46) | MAPK14KDM4EFABP1HSD11B1KCNA5 | |
| SCHEMBL8372826 | 0.66 | PLAU (0.39) | MAPK14KDM4E | |
| SCHEMBL17038887 | 0.66 | FABP1 (0.40) | MAPK14KDM4EHSP90AB1FABP1HSD11B1 | |
| Hydrochloric Acid SCHEMBL8552094 | 0.65 | PLAU (0.38) | MAPK14KDM4E | |
| SCHEMBL23207483 | 0.65 | KDM4E (0.48) | PDK1ADORA2AKDM4EACHE | |
| SCHEMBL12319845 | 0.64 | SIGMAR1 (0.40) | MAPK14HSP90AB1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042649-A2 | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2010-04-15 | — | — | WO | claimed |
| WO-2010042649-A2 | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |