Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776740 | 0.94 | ABCC8 (0.34) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL2777706 | 0.82 | GRIA1 (0.31) | CA1CA2GRIA1GRIA2GRIA3 | |
| SCHEMBL2179051 | 0.79 | GRIA2 (0.45) | CA2ALDH1A1HTTABCC8KCNJ11 | |
| SCHEMBL2777523 | 0.76 | GRIA1 (0.33) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2774471 | 0.73 | GRIA1 (0.42) | CA12CA9CA1CA2ABCC8 | |
| SCHEMBL2778463 | 0.73 | GRIA2 (0.42) | CA1CA2ALDH1A1GRIA1GRIA2 | |
| SCHEMBL2774129 | 0.71 | CCNT1 (0.30) | — | |
| SCHEMBL2776571 | 0.71 | CCNT1 (0.33) | — | |
| SCHEMBL2777136 | 0.68 | GRIA1 (0.36) | ALDH1A1ABCC8KCNJ11GRIA1GRIA2 | |
| SCHEMBL2777119 | 0.68 | CHRNA1 (0.31) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147915-B1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-09-15 | — | — | EP | disclosed |
| US-7741320-B2 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-06-22 | — | — | US | disclosed |
| EP-2147915-A1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2010-01-27 | — | — | EP | disclosed |
| WO-2010004139-A1 | NEW CYCLOALKYLATED BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2010-01-14 | — | — | WO | disclosed |
| US-20100009974-A1 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them | LES LABORATOIRES SERVIER (FR) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009974-A1 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them | ACLY, HCAR1, GABRG1 | CA12 4272/4885CA9 3951/4885CA1 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.